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Patients were randomized (2:1) to one of the following treatment arms: Pemetrexed 500 mg/m2, pembrolizumab 200 mg, and investigators choice of cisplatin 75 mg/m2 or carboplatin AUC 5 mg/mL/min intravenously on Day 1 of each 21-day cycle for 4 cycles followed by pemetrexed 500 mg/m2 and pembrolizumab 200 mg intravenously every 3 weeks

The tumor volume was calculated as follows: V (mm 3 ) = (LW 2 ) / 2 AP probe-net treatment and pathological detection Before treatment, the weight of each mouse and the size of the tumor were measured, and each mouse was photographed

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Lowering inflammatory markers can translate to measurable gains in health and quality of life, which is central to bespoke treatment planning