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Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice

In summary, the use of immune agonists and TME-modulating agents not only amplifies immediate effector responses but also, more importantly, orchestrates the immune system toward the establishment of durable AIM, a paradigm shift essential for overcoming adaptive resistance in cancer immunotherapy

& Frierson, H

Dis Sci (2013) 58:264652

Unlike many anti-inflammatories that are applied to the skin or taken orally, a cortisone shot can help reduce the pain and discomfort almost immediately

[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Highley M.S., Landuyt B., Prenen H., Harper P.C., De Bruijn E.A