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The bibliographies of retrieved papers identified in the search were manually searched for additional relevant articles, and recent recommendations and treatment guidelines were also considered for inclusion

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TAMs are well-known parts of breast cancer microenvironment and most TAMs within TME are closely related to the M2-like phenotype, which participate in almost all metastatic processes, including local invasion, blood vessel intravasation, extravasation at distant sites and metastatic cell growth (287, 288).The hypoxic areas in tumors are related to the accumulation of macrophages, which assist tumor progression by producing angiogenic factors, mitogenic factors and cytokines related to tumor metastasis (289291)

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TauqirSIsrarMRaufBMalikMOHabibSHShahFAet alAcetyl-L-carnitine ameliorates metabolic and endocrine alterations in women with PCOS: a double-blind randomized clinical trial