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Elevated BDNF levels facilitate the shift of microglia from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype, reducing the secretion of cytokines such as IL-1 and TNF

Acetyl-L-carnitine is simply L-carnitine with an acetyl group attached a small chemical change that dramatically improves its ability to cross the blood-brain barrier, making it useful for both physical and cognitive support

Therefore, we compared the effect on GTP levels of EGCG as a Nrf2 inducer plus nicotinamide for naturally regulating ROS levels while boosting NAD + energy to improve endocytosis and autophagy in primary hippocampal neurons across the age span from non-transgenic control and 3xTg-AD mice

Clinical symptoms may not correlate with radiological changes

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XQ-1H regulates Wnt/GSK3/-catenin pathway and ameliorates the integrity of bloodbrain barrier in mice with acute ischemic stroke