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Those with significant weight to lose might benefit most

We will continue to scrutinise the data to see whether abnormal blood test results such as having pre-diabetes might predict a better response to exenatide, and whether there were more of these people in the earlier, smaller trials in which we found positive overall effects. The trial was supported by the UCL Comprehensive Clinical Trials Unit (UCL CCTU), the National Institute for Health and Care Research (NIHR), UCLH Biomedical Research Centre and the NIHR UCLH Clinical Research Facility

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doi: 10.3389/fmed.2021.777861 26 PabelSHamdaniNLueddeMSossallaS

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Duodenal Eosinophils and Mast Cells in Functional Dyspepsia: A Systematic Review and Meta-Analysis of Case-Control StudiesClinical Gastroenterology and Hepatology

The primary pathway increases cyclic AMP (cAMP), a molecule that serves as a secondary messenger amplifying the original GLP-1 signal throughout the cell
