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Acupuncture at acupoints in the abdomen and lower limbs can improve cognitive impairment by regulating the balance of gut microbiota, improving the gut microenvironment, promoting the release of beneficial gut microbiota and neuroactive substances, regulating the immune system
S., & Sahu, N

doi: 10.18632/oncotarget.16173
Most participants reported consuming the full dose, but 36% consumed a lower dose, due to adverse effects at higher dosages (15%) or other non-AE reasons (21%)

However, these 2D models fail to fully reproduce the unraveling complexity of the BBB, and there is still a need for accurate and physiologically relevant BBB models to facilitate the translation of nanomedicines for the treatment of CNS diseases from the laboratory to clinical applications
