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IRP2 is a transcription factor sensitive to intracellular iron levels, modulating the expression of proteins related to iron and lipid metabolism, thus influencing cellular susceptibility to ferroptosis (36)

The pulmonary intravascular glycocalyx, composed of hyaluronan (HA), heparan sulfate proteoglycan (HSPG), Syndecan-1, and Glypican-1, degrades during ALI, reducing lung surface protein expression (e.g., VE-Cadherin, Occludin, VCAM-1, E-selectin) (Chen et al., 2021

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However, the boundaries of these concentrations differ among plant species (Jirage et al

The claim is based on the fact that glutathione is a powerful antioxidant that inhibits melanin production

WB analysis revealed substantially reduced GSDMD level in cochlear tissues of Gsdmd -SC-cKO mice, consistent with successful GSDMD ablation in SCs via immunohistochemistry test (Supplementary Fig