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Deletion of the Gdf8 gene or inhibition of GDF8 protein leads to muscle hypertrophy in many mammals and fish [36-38]

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Activation of D 2 receptors has been shown to blunt cocaine sensitization (Beyer and Steketee, 2002), while D 2 antagonists or receptor knockout generally does not greatly alter acute locomotor activation, sensitization, or CPP (Spyraki et al., 1982

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Higher doses and longer use increase the risk