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During vigorous muscle contraction or during fasting, ATP concentration decreases and AMP concentration increases leading to the activation of AMP-activated protein kinase (AMPK)

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J Neurotrauma 29:25392547 Babikian T, Asarnow R (2009) Neurocognitive outcomes and recovery after pediatric TBI: meta-analytic review of the literature

This is especially practical if you have difficulty with large capsules or don't want to carry multiple pills