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The liver processes blood containing antigens and endotoxins from gut microbiota, triggering immune responses mediated by specialized cells such as Kupffer cells and liver sinusoidal endothelial cells (LSECs)

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The first step in the synthesis of GSH is the formation of -glutamyl-cysteine (GluCys) from the constituent amino acids glutamate and cysteine by the enzyme -glutamyl-cysteine synthetase (GCS, also called glutamate cysteine ligase (GCL))

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