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More specifically, IGF-1 LR3 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, and a 13 amino acid extension peptide at the N terminus from methionyl porcine Growth Hormone [1]

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Urinary or plasma methylmalonic acid (MMA), a substance produced in the body thats dependent on B12, is also helpful for detecting early stages of B12 deficiency