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Both approaches deliver active compounds beneath the skin barrier

Low-dosage melatonin such as 0.3 mg and 1 mg showed significant effects on shortening SOL, while relatively high-dosage melatonin such as 2 mg and 5 mg did not show a significant effect on SOL [84]

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The next part of this review describes available evidence for the effect of angiogenesis inhibitors in breast cancer treatment

Vitamin B1 (as Benfotiamine) 10 mg

Collectively, this suggests the potential for a common pathophysiological mechanism responsible for the neurological symptoms present in the aforementioned disorders