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Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis

(Heme iron, found in meat, fish, and poultry, appears to be absorbed intact.) Ascorbic acid, by maintaining iron in the ferrous state, can enhance the absorption of oral iron, however, the magnitude of this increase is in the range of 10% and only occurs with doses of ascorbic acid, vitamin C of 500 mg or greater

A deficiency of vitamin B12 can also cause shortness of breath or heart palpitations, as well as gastrointestinal symptoms including constipation, diarrhea, appetite loss, or gas

Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025