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4 Transaminase Upregulation and Targeting Amino Acid Synthesis for Cancer Therapy Another means of inhibiting glutaminolysis is to target alanine transaminase through L-cycloserine or aspartate transaminase through the inhibitor amino oxyacetate, which could almost completely halt the growth of breast cancer in xenograft mice [117, 118]

Ideal serum levels of Glutamine to Glutamate appear to be 9 parts Glutamine to 1 part Glutamate, which is mediated by enzymatic conversion in various parts of the body as required by fluctuating levels

Humana Press, 75-86, 2017

J Mol Diagn 21(6):994-1009, 2019

In one phase Ib/II study, 19 patients with R/R AML received combination therapy with azacitidine and avelumab, another PD-L1 inhibitor, with a higher CRR of 10.5%, and two patients achieved CR with thrombocytopenia (Saxena et al., 2021)
