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Another reaction that generates free radicals is the purine metabolism, where xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and subsequently to uric acid, and during its re-oxidation, molecular oxygen is reduced to superoxide [31]
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It can cause uterine hypertrophy, also known as endometrial hyperplasia, which is what causes heavy menstrual bleeding or prolonged bleeding during menstruation
Enzymes of the nudix hydrolase (NUDT) family, specifically NUDT7, NUDT8, and NUDT19, can hydrolyze CoA to 3-phosphoadenosine 5-phosphate (PAP) and 4-phosphopantetheine
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