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Description
Mutation, deletion or inactivation of the gene that encodes ALS in humans and mice decreases circulating levels of IGF-1 and IGFBP-3, causing moderate growth deficiency and abnormalities in bone and carbohydrate metabolism
This assumption is supported by the finding that only the overexpression of GCL, and not of GS, results in increased GSH levels ( The second pathway of GSH synthesis is that related to the recycling of cysteine
10.1080/10937400600882079 [DOI] [PubMed] [Google Scholar] 20.Zoroglu SS, Armutcu F, Ozen S, Gurel A, Sivasli E, Yetkin O, et al
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