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To evaluate mechanisms underlying uncontrolled CMV infection, KTRs were subdivided in controllers patients who are in immunological control of the virus and noncontrollers patients who develop severe, recurring CMV viremia with clinical symptoms (Figure 1A and Supplemental Tables 1 and 2

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For each experiment, two to three rats were decapitated

Monitoring matters

Among the major drugs that are in development, we observe some already in Phase III: inhibitors of the -site amyloid precursor protein cleaving enzyme (BACE) (CNP520, LY3314814, and verubecestat) and antibodies against the A peptide (aducanumab, solanezumab, crenezumab, gantenerumab, and BAN2401) [22, 27]

Not all new entries to the databases are included in this report