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Description
Bridging the gap between experimental findings and real-world use remains the central challenge and will depend on well-designed human studies, improved exposure alignment through standardized kratom preparations, and integration of multi-omics approaches capable of capturing interindividual variability in response and risk
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This is done by stimulating the expression of two vitally important proteins, arylalkylamine-N-acetyltransferase (AANAT) and the transcriptional protein pCREB
Whether more frequent or less frequent administration would be more effective remains unknown
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Structural visualization, image processing, and analysis of docking results were performed using PyMOL 2.5.2
