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Moreover, USP7-mediated decrease of GATA1 poly-ubiquitylation was blocked by the USP7 inhibitors P5091 and P22077 (Figure 5C and Online Supplementary Figure S6B ), demonstrating that the enzymatic activity of USP7 is essential for the USP7-mediated deubiquitylation of GATA1

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However, where possible, consistency and precision across effects were examined

doi: 10.1073/pnas.1035603100

Using genetic and pharmacological approaches to stimulate or antagonize the TGF- pathway in human glioma-initiating cells (GIC), we observed that TGF- exerts an inhibitory effect on c-MET phosphorylation

Cellular triglyceride accumulation in the hepatocytes was inhibited by 10( E ),12( E )-9-oxo-ODE, a ketone produced from LA and isolated from tomato juice, via activation of PPAR in vitro