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STEP 5 Two-Year Safety Results In the STEP 5 trial involving 304 participants (152 receiving semaglutide, 152 receiving placebo), gastrointestinal adverse events occurred in 82.2% of the semaglutide group versus 53.9% of the placebo group over the two-year period

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It targets two appetite hormones instead of one, producing more weight loss in clinical trials: 22.5% of body weight over 72 weeks

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