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Decidual stromal cell-derived exosomes deliver miR-22-5p_R-1 to suppress trophoblast metabolic switching from mitochondrial respiration to glycolysis by targeting PDK4 in unexplained recurrent spontaneous abortion
However, this mechanism is unlikely as (i) GSSG concentration is physiologically in the nanomolar range while a millimolar concentration of BioGSSG is used in vitro and (ii) most proteins have a K ox of around 1 meaning that equimolar concentration of GSH and GSSG are required to reach 50% of glutathionylated protein [107, 108]
There is only a small amount of ATP in cells, but as it is continuously regenerated, the human body can use about its own weight in ATP per day
Although MT3 is not considered a receptor per se, it is roughly a detoxifying enzyme, QR2, which inhibits the electron transfer reactions of quinones, allowing them to modulate and neutralize ROS [21]
