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The different RNA components involved in this process (mRNAs, tRNAs and ribosomal RNAs (rRNAs)) undergo a series of maturation steps such as for instance, splicing, endo- or exonucleolytic cleavages, co- or post-transcriptional modifications (or epitranscriptomic marks) to produce mature, diverse and functional molecules

This approach is coherent with call-to-actions to focus on modifiable risk factors of NDDs when designing interventions (103), and with current diagnosis guidelines that put forward the identification of biomarkers in asymptomatic individuals (65)

This explains how the K3 of HGF II is dislocated from the SEMA of c-MET II, and instead contacts the N domain of HGF I, which then becomes the driving force for the dimerization of two HGFs

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These reversible and heritable modifications do not alter the DNA sequence but instead influence the transcriptional accessibility and gene expression programs critical to CSC identity