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Of particular relevance to IGF-1 anabolic research are TSC2 (relieving inhibition of mTORC1, driving protein synthesis) and FoxO transcription factors (inhibiting their nuclear translocation, blocking expression of atrogenes like MuRF1 and atrogin-1 that drive muscle protein breakdown)

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Methylcobala-min shows its greatest utility with people suffering form acute or chronic degener-ative neurological symptoms, here it is considered as the only promising treat-ment available

Int J Mol Sci (2022) 23:2170

Aliprantis, A

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