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These have included a variety of non-glutamatergic strategies examined in RCTs like: serotonergic modulators, non-steroid anti-inflammatory, estrogen action, lithium, adenosine modulators, azapirones, modafinil, testosterone, oxytocin, pregnenolone, anticholinesterase inhibitors, histamine H 2 blockers, varenicline, davutenide and benzodiazepines [134]

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Notably, pulmonary tissues lack essential substrates for SCFA biosynthesis (e.g., dietary fiber), and germ-free mouse models exhibit significantly reduced pulmonary SCFA levels - direct evidence that lung SCFAs are entirely dependent on functional gut microbiota-derived interorgan supply (Liu Q

Mar 2020;39(3):870-875

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