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A recent meta-analysis conducted by Winterlind, encompassing nine randomized controlled trials, found no notable advantage of NAC over placebo in alleviating cravings across various substance use disorders, despite its well-established modulation of glutamatergic and dopaminergic systems [81]

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David, J., Muniroh, M., Nandakumar, A., Tsuji, M., Koriyama, C., & Yamamoto, M

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Various factors, from genetic predisposition to body composition, type of drinks, length of time drinking and more, all influence how quickly ALDH can break down the toxic acetaldehyde
