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If your pen arrives at room temperature (up to 30C), you can still use it
Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine

Helm, J., Schls, L

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins
[PubMed] Newman, E.A., Glial cell regulation of neuronal activity and blood flow in the retina by release of gliotransmitters

If they dont quite cut through then min is too low
