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Their mechanisms differ, but their goals overlap: appetite suppression, reduced energy intake, and improved glycemic regulation

Retatrutide, like other incretin-based therapies, slows gastric motility

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TZP binds its receptor, leading to the activation of adenylyl cyclase-cAMP-protein kinase A (PKA) pathway and thus stimulating glucose metabolism (glycolysis and Krebs Cycle)

This is relevant, because for the long-term management of vitamin B 12 deficiency, one ampoule is needed every 23 months19 and 56 tablets usually provide 12 months of treatment.20 At 1.4 ampoules per prescription, we expect approximately three to four prescriptions per year and at 56 tablets, we expect 612 prescriptions per year

However, if factors such as the prescribed medications are negatively impacting B12 status then the frequency may well need to be increased to either 6-monthly or 3-monthly