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As GSH reduces hydrogen peroxide (H 2 O 2 ) through GPX, the levels of GSSG, a product of that reaction, rise

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However, for drugs such as lithium, milnacipran, pregabalin, and gabapentin that are not metabolized or little metabolized, and that are eliminated by renal excretion, 10 half-life increases in proportion to the severity of the renal disease

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