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Molecular Biology of G6PD Deficiency The G6PD gene that encodes glucose-6-phosphate dehydrogenase is located on the X chromosome (Xq28) about 1 Mb (million base pairs) from the telomeric end

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Its deficiency is manifested through changes in the number and morphology of erythrocytes, leucocytes and platelets, and by neurological alterations owed to the progressive demineralisation of the nervous system (a consequence of defective myelin synthesis)

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