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Yoo et al., 2020)

Although uterine expression levels of estrogen receptor , G protein-coupled estrogen receptor, and steroid synthase were upregulated in the high-dose group, the decreased expression of connexin 43 and alkaline phosphatase as well as the increased expression of insulin-like growth factor-binding protein three and monoamine oxidase were consistent with decreased estrogen signaling and lower uterine weights

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The review explains that studies on Nrf2 knockout mice have shown disruptions in lens cell architecture, leading to faster cataract development compared to wild-type mice