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Notably, both MG and 7-HMG display G proteinbiased agonism at MOR, preferentially activating G-protein pathways over -arrestin recruitment, a signaling profile that has been hypothesized to underlie improved therapeutic outcomes (Kruegel et al., 2016

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Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites

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For example, mRNA activity levels of SOD and catalase (CAT), an antioxidant enzyme that catalyzes the breakdown of hydrogen peroxide to oxygen and water, were compared in human fibroid cell lines and normal myometrial cells with and without hypoxia treatment [7]