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Once the drug is present on the skin surface, it can diffuse through the epidermis through two routes, either transepidermal(transcellular or intercellular) or transappendageal(sweat ducts, hair follicles, and pilosebaceous glands) [311]

It works by activating downstream biological processes such as: Receptor activation Growth factor upregulation Angiogenesis Cellular signaling cascades These processes continue for weeks after the peptide itself has been cleared from circulation

It also promotes the production of other important skin components elastin, proteoglycans and glycosaminoglycans , keeping the skin firm and plump

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Terpenoids such as eugenol and trans-anethole have been reported to possess significant antioxidative effects, which can lead to improved glucose metabolism and reduced OS markers in diabetic rats (Kokabiyan et al., 2023

Questo effetto si verificato anche quando i ratti sono stati trattati con corticosteroidi (che possono rallentare il processo di guarigione) 31, 33, 34