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Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

The therapy as a shared effect, noted in the severe ischemia condition, as well as in advanced reperfusion, consistently and rapidly counteracts occlusion/occlusion-like syndrome as a whole, restoring function by effectively bypassing loops of minor vessels (e.g., direct blood flow [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168] via the azygos vein) to counteract the failure of major vessels [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168]

M.PescadorD.Da CasaC.GmezV.RedondoA

12 GuZ.-F.Yu-DuoH.WangT.-YuCaiP.-L.ZhangY.DengK.-J.et al (2024)

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It became the basis for all subsequent dermatological applications and cosmetic formulations with copper peptide complex