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This polarization is characterized by the expression of specific markers, including MHC-II molecules, CD80, and CD86 on the cell surface, alongside a cytokine profile featuring high levels of IL-12 and IL-23, but low IL-10 ( While M1-secreted mediators initially help clear pathogens, persistent M1 activation may lead to cytotoxic tissue injury ( 2.1.2 M2 macrophages Upon induction by Th2 cytokines such as IL-4, IL-13, IL-10, and transforming growth factor- (TGF-), polarized M2 macrophages release anti-inflammatory factors like IL-1, IL-10, and TGF-

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10.1006/dbio.2000.9832 [DOI] [PubMed] [Google Scholar] Johnson JW, & Ascher P (1987)