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Similarly, pyruvate dehydrogenase kinase-1 (PDK1), another crucial glycolytic enzyme, has been demonstrated to initiate autophagy in AML cells by interacting with the key autophagy molecule ULK1 (Unc-51 like kinase-1) [47]

An injectable and self-healing hydrogel with controlled release of curcumin to repair spinal cord injury

As a part of protection, both neurotransmitters, glutamate as well as GABA, are taken up by adjacent astrocytes and subsequently converted to glutamine (Chen et al

GLS1 is an especially attractive target given the emergence of several small molecule allosteric inhibitors [121]

In a randomized, double-blind, placebo-controlled trial, daily supplementation with Lactobacillus plantarum ECGC 13110402 for 12 weeks in adults with moderate hypercholesterolemia resulted in a significant reduction in LDL cholesterol and hs-CRP compared to placebo, suggesting a direct benefit of probiotics on cardiovascular risk markers in humans (Zhou et al., 2023)

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