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These findings support a mechanistic link between thyroid dysfunction, fibrotic ECM remodeling, and hepatic carcinogenesis, positioning ECM stiffness as a critical pathogenic nexus in the transition from MAFLD to HCC (157)

Of the 11 peptides, five were shown to have inhibitory effect against the angiotensin-converted enzyme (ACE), three to have antimicrobial activity, one to be antioxidative, another to be antithrombotic, and the final one to be an inhibitor of dipeptidyl peptidase IV

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