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Tumors from moderate-mutant groups showed significant upregulation of pathways associated with mitochondrial translation (e.g., Mrpl, Mrps), mitochondrial gene expression, and OXPHOS (e.g., Cox5a, Coq9, Atp5pf, Shmt2, Tafazzin, Ndufb2, Ndufab1, Uqcrh) (Fig

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