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These results also indicate the ability of sertraline or imipramine to alleviate chronic stress due to repeated forced swimming

For example, heat shock proteins 27 (Hsp27) and 25 (Hsp25) in humans and mice (L929 fibroblasts) give protection against H 2 O 2 by raising levels of reduced GSH [132]

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This decrease in production can be due to a number of factors, including a decrease in the activity of enzymes needed for glutathione production, a decline in the level of nutrients needed for glutathione production, and damage to cells and tissues that impairs their ability to produce glutathione

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