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As natural, biocompatible, and often orally available nanocarriers, they shuttle plant bioactive cargos across biological barriers to inflammatory sites

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In fact, POI patients often exhibit systemic changes such as metabolic abnormalities (e.g., increased waist circumference, alterations in lipid and glucose levels) and dysregulation of signaling pathways (e.g., changes in the phosphorylation levels of key molecules such as PI3K, AKT, and mTOR), yet these critical indicators are frequently overlooked in current research

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While modifications have yielded aptamers with K d values ranging from picomolar to millimolar, those with picomolar and nanomolar affinities are generally preferred