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In addition to dioxygenase enzymes that drive histone and DNA demethylation, KG also serves as a substrate for a class of prolyl 4hydroxylase enzymes, which mediate the ubiquitination and degradation of hypoxiainducible factor 1 (HIF1), a key transcription factor that facilitates the cellular adaptation to low oxygen levels (Fig 3)

doi: 10.2337/diacare.25.11.2010 84 LsethSMellgrenSIJordeRLindalSStlbergE

Although there are currently no US Food and Drug Administration-approved anti-fatigue medications, certain medications can be used to relieve fatigue-associated symptoms

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Garzon, R, Pichiorri, F, Palumbo, T, Visentini, M, Aqeilan, RI, Cimmino, A, Wang, H, Sun, HL, Volinia, S, Alder, H, Calin, GA, Liu, C, Andreeff, M , Croce, CM Correction to