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Autophagy deficiency in neurons results in buildup of ubiquitinated proteins, dystrophy of neural terminals, impairments in synaptic transmission, and eventually, neurodegeneration observed in both neurodegenerative and neurodevelopmental disorders [245, 249, 250]

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2022;73 doi: 10.1016/j.amsu.2021.103145.103145 [DOI] [PMC free article] [PubMed] [Google Scholar] 151.Malekinejad Z., Baghbanzadeh A., Nakhlband A., et al

Whole lanes were cut into 3 individual slices, proteins therein were in-gel digested with trypsin, and generated peptides were analyzed by an LC-MS system consisting of an Orbitrap Velos mass spectrometer coupled to an Ultimate 3000 RSLC nanoflow system (Thermo Fisher Scientific)