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Specific reasons why remain unknown, but it is likely that some of the counter apoptotic mechanisms that occur during the development of T-cell memory or the process of chronic HIV infection are at least partially responsible
It is better understood as a significant vulnerability factor that interacts with genetics, stress exposure, and neuroinflammation to influence mood regulation

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This ultimately impairs IVD biomechanical properties, subsequently leading to structural alterations and development of discogenic LBP, as well as more severe sequelae, including disc herniation, spinal instability, and stenosis with serious neurological consequences (Roberts et al., 2006)
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Health anxiety disorders: a cognitive construal
