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Based on these findings, this review summarizes the pathophysiological mechanisms underlying EDC, with a particular focus on how chronic inflammation contributes to its development and progression through pathways involving neurotransmitter imbalance, HPA axis dysregulation, and impaired synaptic plasticity

doi: 10.1016/0959-8049(96)00185-2

Steketee, 1998

: 201911: 450

However, the increase in molar ratio is entirely explained by the fact that IGF-I and IGFBP-3 increase with the same number of moles per liter, but with a larger relative increase in IGF-I than IGFBP-3 and with IGF-II molar concentrations being unchanged (112)