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E., Romanowski, A., Caldart, C

Pathogenic, therapeutic, or diagnostic

The introduction of miR-351-5p (the target of circPtpn14) was found to reverse the 5-LOX upregulation and ER stress signaling activation caused by circPtpn14 overexpression alone and to rescue the decreased cell viability, inhibition of GPX activity, and increased blood-brain barrier permeability in vitro caused by circPtpn14 Wu et al

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Differential gene expression in wild type and cir1 plants without pathogen challenge were examined using a microarray biased toward defense-response and signaling genes in order to identify transcripts required for resistance