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Acknowledgements The authors are supported by the grants FIS PI13/00047, ISCIII-RETIC REDinREN RD12/0021, Comunidad de Madrid S2010/BMD-2378, CYTED IBERERC, Programa Intensificacin Actividad Investigadora (ISCIII) to A.O., and FIS Sara Borrell to M.D.S.-N