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Previous studies revealed that the polysaccharides of BP (Chinese wolfberry) have immunomodulatory activity in vitro against RAW 264.7 cells via downregulating the level of tumor necrosis factor-alpha (TNF-), interlukin-1 (IL-1), interlukin-6 (IL-6), and nitric oxide (NO) secretion (162)

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In contrast, molecular techniques such as PFGE and MLST provide high resolution for epidemiological and phylogenetic analyses but require substantial investments in equipment, reagents, and bioinformatics infrastructure

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The phosphorylated IRF3 and IRF5 translocate to the nucleus and promote the production of type I interferon ( Figure 2 )

Westhaus A, Blumrich EM, Dringen R (2017) The antidiabetic drug metformin stimulates glycolytic lactate production in cultured primary rat astrocytes
