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Forum Support in reply to As an aside, we are unsure if the fatigue is purely down to B12 deficiency or if its long covid" If your B12 deficiency is not due to diet, I'd expect GP to at least test you for PA and Coeliac disease, two autoimmune conditions that can lead to B12 deficiency

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On induction with interferon- (IFN-), the constitutive 1, 2 and 5 subunits of 20S proteasome are replaced by catalytically active inducible 1i (PSMB9), 2i (PSMB10) and 5i (PSMB8) subunits referred as the immunoproteasome 24,25

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The product of this sulfurisation step, -glutamylhercynylcysteine sulfoxide, is processed by EgtC, a glutamine amidotransferase, which cleaves the -glutamyl residue to yield hercynylcysteine sulfoxide