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3.2 Regulation of HPA-axis The HPA-axis involves three hormones [i.e., corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol] and mainly mediates stress in the human body (81)

234 It remains to be explored whether these substitutions contribute to the etiology of folding-related diseases or whether they have other physiological functions that are not currently understood

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