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[15] [18] Always tell your healthcare provider about every medicine and supplement you take so dosing and monitoring can be adjusted

doi: 10.1001/jamaoncol.2017.3064 101 PyzikAGrywalskaEMatyjaszek-MatuszekBSmolenAPyzikDRolinskiJ

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The second one is the low number of patients in the included trials (only 1625 patients from 17 RCTs)