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Burgos-Morn E, Abad-Jimnez Z, Martnez de Maran A, Iannantuoni F, Escribano-Lpez I, Lpez-Domnech S, et al

High concentrations for IV use should be diluted in normal saline or another compatible IV fluid before administration

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Furthermore, studies suggest that Vitamin C can inhibit the action of histidine decarboxylase, the enzyme responsible for the de novo synthesis of new histamine